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KMID : 0378019730160110059
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New Medical Journal
1973 Volume.16 No. 11 p.59 ~ p.65
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The Effect of Lithium Chloride on the Circulatory System and Excised Intestine of Rabbits
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南在重/Nam, Jae Joong
玄悳燁/洪權熹/金陽順/Hyun, Duk Yeup/Hong, Kown Hee/Kim, Yang Soon
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Abstract
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Until 1949, lithium chloride was used as a substitute for sodium chloride in patients with congestive heart failure for whom sodium-free diet were prescribed. But it´s clinical use was banned by the toxicity of the lithium ion. Since the mid-1950s, owing particularly to the efforts of Schou, lithium salts has been used extensively in the treatment of manic-depressive psychosis, and many studies have been made about it.
In this paper the effect of lithium chloride on the blood pressure, contractile effect of the excised auricle and intestine, and catecholamine contents in heart muscle of the rabbits were investigated. The results obtained were summarized as follows:
1. Large dose (50mg/kg) of lithium chloride elevated blood pressure and inhibited norepinephrine response on the blood pressure.
2. Large dose (47.2mM) of lithium chloride increased contractile effect of the isolated auricle and inhibited epinephrine response on the isolated auricle.
3. Large dose (47. 2mM) of lithium chloride decreased contractility of the isolated intestine and inhibited epinephrine response on the isolated intestine.
4. Cardiac catecholamine contents were decreased by the treatment of lithium chloride(25mg/kg) for 5 days.
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